This course is part of an integrated science learning experience combining microbiology, biogeochemistry, hydrology, and mathematical modeling using the new Hampshire College Kern Center, built to the Living Building Challenge Standard, as a case study. Students will meet twice a week to explore the science behind the systems of the living building in their specific discipline. Once a week all three classes will meet together to complete interdisciplinary projects, share expertise, and form a collaborative science learning community. Students will read and share primary literature, complete problem sets, and work collaboratively on projects. We will learn about the campus living building from the architects and design engineers, take field tours, and meet faculty across campus engaged with the project. Students who complete this course may choose to continue their work using the living building in NS280, Collaborative Design Projects, during the spring semester. Students enrolled in NS-140T: Modeling Systems, will use mathematical models to build our understanding of the processes occurring in the living building. We will learn how to build mathematical models, simulate solutions, and investigate dynamics. We will then build models to explore the cycling of water, carbon and nutrients, and the microbial processes involved in water and waste treatment in the living building.